Table 1.
Baseline Hemodynamic Values Prior to Commencement of Treatment in mRen2.Lewis Hypertensive Rats.
| Variable |
Vehicle (n = 9) |
Valsartan (n = 10) |
Combination (n = 10) |
|---|---|---|---|
| Systolic arterial pressure, mm Hg | |||
| 24 h average | 202 ± 4 | 203 ± 2 | 203 ± 4 |
| Diurnal average | 206 ± 4 | 207 ± 2 | 208 ± 4 |
| Nocturnal average | 198 ± 3 | 200 ± 2 | 199 ± 3 |
| Diastolic arterial pressure, mm Hg | |||
| 24 h average | 146 ± 3 | 144 ± 2 | 143 ± 3 |
| Diurnal average | 150 ± 4 | 149 ± 2 | 147 ± 3 |
| Nocturnal average | 141 ± 2 | 140 ± 2 | 138 ± 2 |
| Mean arterial pressure, mm Hg | |||
| 24 h average | 173 ± 3 | 173 ± 2 | 172 ± 3 |
| Diurnal average | 177 ± 4 | 178 ± 2 | 177 ± 3 |
| Nocturnal average | 169 ± 2 | 169 ± 2 | 168 ± 3 |
| Pulse pressure, mm Hg | |||
| 24 h average | 56 ± 4 | 59 ± 2 | 60 ± 3 |
| Diurnal average | 56 ± 4 | 58 ± 2 | 60 ± 3 |
| Nocturnal average | 56 ± 4 | 60 ± 2 | 61 ± 3 |
| Heart Rate, beats/min | |||
| 24 h average | 357 ± 4 | 366 ± 4 | 360 ± 2 |
| Diurnal average | 331 ± 5 | 335 ± 5 | 329 ± 3 |
| Nocturnal average | 383 ± 6 | 396 ± 4 | 390 ± 2 |
| Awake/asleep ratio, (%) | −5 ± 1 | −5 ± 1 | −5 ± 1 |
Values are means ± SEM. Diurnal averages are values between 6:00 and 18:00 h. Nocturnal averages are values between 18:00 and 6:00 h.