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. Author manuscript; available in PMC: 2013 Nov 26.
Published in final edited form as: J Med Chem. 2012 Nov 8;55(22):9669–9681. doi: 10.1021/jm300908t

Figure 1.

Figure 1

QS in Vibrio cholerae. a) The CAI-1 AI (green circles)is produced by the CqsA synthase. Under conditions of low CAI-1 concentration the cognate receptor, CqsS acts as a kinase, and transfers phosphate to LuxO which leads to the expression of genes underpinning individual behaviors. b) At high CAI-1 concentrations, CqsS binds CAI-1 and this converts CqsS from a kinase to a phosphatase. LuxO is dephosphorylated which leads to the expression of genes required for group behaviors. c) The native CAI-1 QS molecules in V. cholerae.