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. Author manuscript; available in PMC: 2013 Nov 26.
Published in final edited form as: J Med Chem. 2012 Nov 8;55(22):9669–9681. doi: 10.1021/jm300908t

Table 1. Simple ester and amide CAI-1 analogs.

Entry Compound EC50 (nM)a % Responseb
1 graphic file with name nihms420498t1.jpg 38±3 100±4
2 graphic file with name nihms420498t2.jpg 24±2 106±15
3 graphic file with name nihms420498t3.jpg 670±240 94±35
4 graphic file with name nihms420498t4.jpg 180±170 108±4
5 graphic file with name nihms420498t5.jpg 1,500±220 81±11
6 graphic file with name nihms420498t6.jpg 28±2 106±4
7 graphic file with name nihms420498t7.jpg 30±2 108±3
8 graphic file with name nihms420498t8.jpg 33±2 107±3
a

Values were determined using a light-based CqsS agonist bioassay, see Supporting Information. All EC50 values are the mean of triplicate analyses with the range defining the 95% confidence interval.

b

Percent maximal bioluminescence, with respect to CAI-1, which is set at 100%. The range defines the 95% confidence interval.