Table 1. Simple ester and amide CAI-1 analogs.
Entry | Compound | EC50 (nM)a | % Responseb |
---|---|---|---|
1 | 38±3 | 100±4 | |
2 | 24±2 | 106±15 | |
3 | 670±240 | 94±35 | |
4 | 180±170 | 108±4 | |
5 | 1,500±220 | 81±11 | |
6 | 28±2 | 106±4 | |
7 | 30±2 | 108±3 | |
8 | 33±2 | 107±3 |
Values were determined using a light-based CqsS agonist bioassay, see Supporting Information. All EC50 values are the mean of triplicate analyses with the range defining the 95% confidence interval.
Percent maximal bioluminescence, with respect to CAI-1, which is set at 100%. The range defines the 95% confidence interval.