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. Author manuscript; available in PMC: 2013 Nov 26.
Published in final edited form as: J Med Chem. 2012 Nov 8;55(22):9669–9681. doi: 10.1021/jm300908t

Table 2. CAI-1 ester chain-length analogs.

Entry Compound EC50 (nM)a % Responseb
1 graphic file with name nihms420498t9.jpg >50000 23c
2 graphic file with name nihms420498t10.jpg 1,000±160 84±27
3 graphic file with name nihms420498t11.jpg 350±59 104±9
4 graphic file with name nihms420498t12.jpg 73±12 92±26
5 graphic file with name nihms420498t13.jpg 720±270 74±9
a

Values were determined using a light-based CqsS agonist bioassay, see Supporting Information. All EC50 values are the mean of triplicate analyses with the range defining the 95% confidence interval.

b

Percent maximal bioluminescence, with respect to CAI-1, which is set at 100%. The range defines the 95% confidence interval.

c

The maximal % response at the maximum concentration tested (50,000 nM).