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. Author manuscript; available in PMC: 2013 Nov 26.
Published in final edited form as: J Med Chem. 2012 Nov 8;55(22):9669–9681. doi: 10.1021/jm300908t

Table 3. Polar CAI-1 ester analogs.

Entry Compound EC50 (nM)a % Responseb
1 graphic file with name nihms420498t14.jpg 4,400±450 96±8
2 graphic file with name nihms420498t15.jpg >50,000 31c
3 graphic file with name nihms420498t16.jpg 2,400±300 91±9
4 graphic file with name nihms420498t17.jpg 10,000±1,800 95±15
a

Values determined using a light-based CqsS agonist bioassay, see Supporting Information. All EC50 values are the mean of triplicate analyses with the range defining the 95% confidence interval.

b

Percent maximal bioluminescence, with respect to CAI-1, which is set at 100%. The range defines the 95% confidence interval.

c

The maximal % response at the maximum concentration tested (50,000 nM).