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. Author manuscript; available in PMC: 2013 Nov 26.
Published in final edited form as: J Med Chem. 2012 Nov 8;55(22):9669–9681. doi: 10.1021/jm300908t

Table 5. Aryl- and cyclohexyl-substituted CAI-1 ester analogs.

Entry Compound EC50 (nM)a % Responseb
1 graphic file with name nihms420498t30.jpg 1,100±270 59±22
2 graphic file with name nihms420498t31.jpg 231±15 93±6
2a graphic file with name nihms420498t32.jpg 151±20 92±13
3 graphic file with name nihms420498t33.jpg 310±51 82±10
4 graphic file with name nihms420498t34.jpg 84±6 97±6
5 graphic file with name nihms420498t35.jpg 190±27 95±9
6 graphic file with name nihms420498t36.jpg 190±19 100±6
6a graphic file with name nihms420498t37.jpg 117±12 94±11
7 graphic file with name nihms420498t38.jpg 3,700±580 83±13
8 graphic file with name nihms420498t39.jpg >50,000 llc
9 graphic file with name nihms420498t40.jpg 680±84 85±8
10 graphic file with name nihms420498t41.jpg 1,600±210 79+10
11 graphic file with name nihms420498t42.jpg 190±17 98±6
12 graphic file with name nihms420498t43.jpg 9,400±3,600 60±53
13 graphic file with name nihms420498t44.jpg >50,000 28c
a

Values determined using a light-based CqsS agonist bioassay, see Supporting Information. All EC50 values are the mean of triplicate analyses with the range defining the 95% confidence interval.

b

Percent maximal bioluminescence, with respect to CAI-1, which is set at 100%. The range defining the 95% confidence interval.

c

The maximal % response at the maximum concentration tested (50,000 nM).