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. 2013 Aug 26;65(9):2290–2300. doi: 10.1002/art.38026

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Copyright © 2013 The Authors. Arthritis & Rheumatism is published by Wiley Periodicals, Inc. on behalf of the American College of Rheumatology. This is an open access article under the terms of the Creative Commons Attribution-NonCommercial License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes.

Re-use of this article is permitted in accordance with the Creative Commons Deed, Attribution 2.5, which does not permit commercial exploitation.

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Alterations in gene expression are reversible. A and B, Immunostaining (left) and morphometric quantification (right) of type II collagen (top) and tartrate-resistant acid phosphatase (TRAP) (bottom) in distal interphalangeal joints during (0–6 weeks) and after (weeks labeled −1 to −3) doxycycline stimulation (n = 4 mice per group). Bars = 100 μm. C and E, Transcriptional alterations of the indicated genes in paws of doxycycline-inducible human tumor necrosis factor α (hTNFα)–transgenic mice (n = 9 paws per group). Values are the mean ± SEM. D and F, Relationship between human TNFα and indicated mRNAs in paws of doxycycline-inducible human TNFα–transgenic mice treated for 6 weeks with doxycycline (n = 23 paws). Mean mRNA levels in untreated mice were assigned a value of 1. Osx = osterix; Coll. I = type I collagen; MMP-3 = matrix metalloproteinase 3; Cath. K = cathepsin K. ∗ = P < 0.05; ∗∗ = P < 0.01; ∗∗∗ = P < 0.001; ∗∗∗∗ = P < 0.0001.