Table 2.

Best predictive value of the blood BNP of the indomethacin treatment for hsPDA according to the criteria adopted in our NICU

BNP concentration	Group I	Group N
≥250 pg/mL	12	6
<250 pg/mL	8	20

BNP, B-type natriuretic peptide; hsPDA, haemodynamically significant patent ductus arteriosus; NICU, neonatal intensive care unit.

When the cut-off value of the BNP for hsPDA was set to 250 pg/mL for predicting the necessity of indomethacin, it generated an odds ratio as high as 5.0 (95% CI, 1.4 to 17.9, p = 0.016); indomethacin administration rate was 66.7%, while DA spontaneous closure rate was 71.4%.