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. 2013 Jun 20;52(30):7709–7713. doi: 10.1002/anie.201303282

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© 2013 The Authors. Published by Wiley-VCH Verlag GmbH & Co. KGaA. This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.

Re-use of this article is permitted in accordance with the Creative Commons Deed, Attribution 2.5, which does not permit commercial exploitation.

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JmjC demethylases catalyze dealkylation and hydroxylation reactions. Mass spectra of incubations of a) ART-Lys(Me₃)-QTAR-Lys(Me/Et)-STGGKA + JMJD2E, b) ART-Lys(Me₃)-QTAR-Lys(Me/Et)-STGGKA + PHF8, c) PATGGV-Lys(Me/Et)-KPHRY + FBXL11, d) ART-Lys(Me₃)-QTAR-Lys(iPr)-STGGKA + JMJD2E, e) ART-Lys(Me₃)-QTAR-Lys(iPr)-STGGKA + PHF8, f) ART-Lys(Me₃)-QTAR-Lys(Me/iPr)-STGGKA + JMJD2E, g) PATGGV-Lys(Me/iPr)-KPHRY + FBXL11, h) ART-Lys(Me₃)-QTAR-Orn(Me₂)-STGGKA + PHF8, and i) PATGGV-Orn(Me₂)-KPHRY + FBXL11. Spectra of the corresponding substrate peptides are shown in red. MS timecourses for selected reactions: j) ART-Lys(Me₃)-QTAR-Lys(Me/Et)-STGGKA + JMJD2E, k) ART-Lys(Me₃)-QTAR-Lys(Me/Et)-STGGKA + PHF8, l) ART-Lys(Me₃)-QTAR-Lys(Me/iPr)-STGGKA + JMJD2E.