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. 2013 Oct 14;8:3945–3953. doi: 10.2147/IJN.S44363

Figure 2.

Figure 2

Internalization of gold nanoparticles into terminally differentiated superficial urothelial cells of the AuNPs-N animals.

Notes: (A) LM; no brown labeling is seen in the urothelium or in the blood vessels of the bladder wall. (B) SEM; differentiated superficial urothelial cells are large homogenous, polygonal cells. (C) TEM; superficial cells contain fusiform vesicles, but no gold nanoparticles. (D) TEM; superficial cell contains membrane compartments with gold nanoparticles (arrows; magnification in [E]). (F) TEM; in the urinary bladder endothelial cells, no nanoparticles are observed; asterisk*: vein lumen. Bar length is 10 μm (A and B), 500 nm in (C), and 250 nm in (D–F). Arrows show position of cells.

Abbreviations: b, basal cells; en, endothelial cells; FVs, fusiform vesicles; i, intermediate; LM, light microscopy; S, superficial; SEM, scanning electron microscopy; TEM, transmission electron microscopy; V, blood vessels; AuNPs-N animals, animals that were fed with normal diet and were then injected with AuNPs; AuNPs, ultra-small gold nanoparticles.