Table 1.
Candidate genes most studied in association with bipolar disorder
| Gene symbol | Gene name | Single nucleotide polymorphisms studied | Result | Reference |
|---|---|---|---|---|
| 5-HTT | Serotonin transporter | 956304, rs25528, rs6354, rs6355, rs6353, rs6352, rs1042173, rs1532042 | Protective haplotype | 5 |
| rs1050565, rs2020934, rs2066713, rs2020936, rs2020937, rs2020938, rs2020939, rs140701, rs3794808, rs3813034 | Negative | 6–8 | ||
| BDNF | Brain-derived neurotrophic factor | Val/Met (rs6265) | Positive | 9–17,25 |
| Val/Met (rs6265) | 18–23 | 18–23 | ||
| rs988748-(GT)n-rs6265; rs1519480, rs12273363, rs11030107; rs1519480, rs7127507 rs2030324, rs2883187 | Positive | 17,26,27 | ||
| COMT | Catechol-O-methyltransferase | Val/Met | Positive | 36,37 |
| Val/Met | Negative | 29–35 | ||
| rs737865, rs165688, rs165599, rs2097603 | Positive | 35,38,39 | ||
| DISC1 | Disrupted in schizophrenia 1 | rs1407598, rs1407598, rs1535529, rs3524; rs1538977, rs2492367, rs2812393, rs1322784; rs1538979, rs821577; rs766288, rs3738401, rs2492367, rs6675281, rs12133766, rs1000731, rs7546310 and rs821597; rs2738864(C)-rs16841582(C) | Positive | 41–46 |
| A844G, C1348T, C1446T, C1460T, T1595C, C14T, T11870C, G11160A, C11085A, C9481T, G1916A, T2163A, G2304C, C3215T, G65049 | Negative | 47 | ||
| DTNBP1 | Dysbindin | rs2619538; P1757 and P1320; rs3213207, rs1011313, rs2005976, rs760761, rs2619522; P1763 | Positive | 48–51 |
| DAOA | D-amino acid oxidase activator | rs1935058, rs1341402, rs2391191, rs1935062, rs947267, rs954581; M12, rs1341402, M15 (rs2391191), rs1935062, M19 (rs778294), M23, M24; rs746187 (M7), rs3916966 (M13), rs3916972 (M25); rs746187-G and rs3916972-G | Positive | 54–58 |
| Meta-analysis | Negative | 59 | ||
| NRG1 | Neuregulin 1 | SNP8NRG221533, SNP8NRG241930, SNP8 NRG243177 (rs6994992) | Positive | 61,62 |
| SNP8NRG221533, 478B14-878, 420M9–139, SNP8 NRG243177, D8S1810 | Negative | 63 |