Table 2.
Serum PON1 activity, serum TAOP and TPEROX levels, and status of OSI in the olanzapine, quetiapine, and HC groups
| Olz (n=35) |
Quet (n=29) |
HC (n=32) |
Statistics | |
|---|---|---|---|---|
| PON1 (U/L) | 93 (42–294) | 156 (40–529) | 156.5 (56–520) |
df =2, P=0.008 Olz and Quet: P=0.014 Olz and HC: P=0.04 Quet and HC: P=0.91 |
| TAOP (mmol trolox equivalent/L) | 1.95 ± 0.23 | 2.05 ± 0.33 | 2.06 ± 0.29 | F =1.57, P=0.21 |
| TPEROX (mmol H2O2 equivalent/L) | 6.51 ± 2.11 | 6.93 ± 3.7 | 6.57 ± 2.29 | F =0.20, P=0.81 |
| OSI (TPEROX mmol H2O2 equivalent/L)/(TAOP mmol trolox equivalent/L) | 0.34 ± 0.11 | 0.33 ± 0.14 | 0.32 ± 0.11 | F =0.12, P=0.88 |
Notes: Significant difference between groups is highlighted in bold. PON1 is presented as median (range); TAOP, TPREOX, and OSI are presented as mean ± standard deviation.
Abbreviations: H2O2, hydrogen peroxide; HC, healthy control; Olz, olanzapine group; OSI, oxidative stress index; PON1, paraoxonase 1; Quet, quetiapine group; TAOP, total antioxidant potentials; TPEROX, total peroxide level.