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Diagram depicting a speculative mechanism of PABPN1-mediated decay. Symbols: PABPN1 (oval inscribed with “N”), PAPα/PAPγ (rectangle inscribed with “α/γ”), RRP6 and DIS3 (pacman symbols), core exosome (ring of ovals), lower case “a” in poly(A) tails denotes hyperadenylation. Note that PABPN1 is not depicted on the initial poly(A) tail for simplicity and is not meant to imply any mechanisms for PABPN1 in the initial polyadenylation event (see Discussion).
