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. 2013 Oct 17;9(10):e1003257. doi: 10.1371/journal.pcbi.1003257

Table 1. List of predicted 39 high priority malaria targets and their TDR ranking.

IDa Protein TDR Ranking
Kinases:
PFL1490w atypical protein kinase, RIO family, putative 1536
PFB0815w calcium dependent protein kinase 1 (CDPK1) 409
PFF0520w calcium-dependent protein kinase (CDPK2) 180
PFC0420w calcium dependent protein kinase 3 (CDPK3) 143
PF07_0072 calcium dependent protein kinase 4 (CDPK4) 180
PF13_0211 calcium dependent protein kinase 5 (CDPK5) 180
PFI1685w * cAMP-dependent protein kinase catalytic subunit (PKAc) 27
PFL1110c cAMP-dependent protein kinase regulatory subunit (PKAr) 857
PF11_0377 casein kinase 1 (CK1) 16
PF14_0346 * cGMP-dependent protein kinase (PKG) 69
PF14_0294 mitogen-activated protein kinase 1 (MAP1) 637
PFA0515w phosphatidylinositol-4-phosphate 5-kinase (PIP5K) 637
MAL13P1.279 * protein kinase 5 (PK5) 3
PFB0150c protein kinase, putative 914
PFL2250c * RAC-beta serine/threonine protein kinase (PKB) 27
PFC0385c serine/threonine protein kinase, putative (ARK2) 341
PF14_0516 serine/threonine protein kinase, putative (KIN) 710
PF11_0488 serine/threonine protein kinase, putative 1536
PFL2280w serine/threonine protein kinase, putative 379
PFC0105w serine/threonine protein kinase (SRPK1) 637
Proteases:
PF11_0165 * cysteine proteinase falcipain 2a 10
PF11_0161 * cysteine proteinase falcipain 2b (FP2B) 50
PF11_0162 * cysteine proteinase falcipain 3 50
PF14_0076 * plasmepsin I (PMI) 39
PF14_0077 * plasmepsin II 39
PF14_0075 * plasmepsin IV (PM4) 39
PFC0495w * plasmepsin VI 86
Other Enzymes:
PFD0830w * bifunctional dihydrofolate reductase-thymidylate synthase (DHFR-TS) 3
PF13_0262 lysine-tRNA ligase, putative 409
PFI1310w NAD synthase, putative 409
PFI0380c * peptidyl deformylase (PDF) 2
PFA0480w phenylalanyl-tRNA synthetase, putative 180
PFD0305c vacuolar ATP synthase subunit b 112
Transporter/Channels:
PF14_0244 ABC transporter, (EPP family), putative 637
PFE1150w multidrug resistance protein (MDR1) 571
PF08_0113 vacuolar proton translocating ATPase subunit A, putative 876
Other Proteins:
PFI0180w * alpha tubulin 1 306
PFD1050w alpha tubulin 2 857
PF10_0084 * tubulin beta chain 74
a

Identifiers and protein names taken from PlasmoDB [74]. Targets with known ligands according to TDR Targets database are marked with an asterisk (*) [27]. Essential kinases according to Solyakov et al. are shown in italics [18].