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. 2013 Oct 17;9(10):e1003252. doi: 10.1371/journal.pcbi.1003252

Figure 6. Interplay of transcription factors and signaling proteins in specifying the regulatory programs of modules.

Figure 6

A. Shown are the fraction of modules that are regulated by TFs alone, signaling proteins alone or both B. Shown are the co-regulatory, genetic and protein-protein interactions between regulators associated with HOG1 associated modules. HOG1 is a protein kinase involved in osmotic stress and cell wall organization. HOG1 is predicted to be a regulator for Modules 2 and 37, and is known to be directly upstream of SKO1 which is predicted to regulate genes in Module 19. Co-regulatory relations are inferred between two regulators if they share common targets. Genetic and protein-protein interactions are obtained from BioGRID [66].