Table 3. Factors associated with secondary infection in all contacts <50 years vaccinated within 8 days post exposure according to protocol (n=72).
| Vaccinated per-protocol <8 days post-exposure | Symptomatic secondary infection and/or PCR positivea
|
Univariablec
|
||||||
|---|---|---|---|---|---|---|---|---|
|
|
RR (95%CI) | p valueb | ||||||
| N | n | % | ||||||
| Total | 72 | 5 | 6.9 | |||||
| Age group | ||||||||
| <=15 | 40 | 1 | 2.5 | 1.0 | ||||
| 16-40 | 22 | 1 | 4.5 | 1.8 (0.1-28.9) | ||||
| 41+ | 10 | 3 | 30.0 | 12.0 (1.3-106.7) | 0.035 | |||
| Gender | ||||||||
| Female | 36 | 4 | 11.1 | |||||
| Male | 36 | 1 | 2.8 | 0.3 (0.0-2.2) | 0.210 | |||
| Household sizee | ||||||||
| 2 persons | 9 | 1 | 11.1 | 1.0 | ||||
| 3-5 persons | 29 | 3 | 10.3 | 0.9 (0.1-8.3) | ||||
| 6 or more persons | 34 | 1 | 2.9 | 0.3 (0.0-4.1) | 0.530 | |||
| Ethnic background | ||||||||
| Non-Western | 38 | 2 | 5.3 | 1.0 | ||||
| Dutch/western | 34 | 3 | 8.8 | 1.7 (0.3-10.2) | 0.574 | |||
| Interval between exposure & vaccination, mean days (standard deviation) | 4.5 (1.7) | 3.4 (2.6) | 0.7f (0.4-1.3) | 0.223 | ||||
a
Of the 5 secondary infections included in this analysis, one was a child aged 1 who was asymptomatic, but PCR positive.
b. Wald test.
c
All analyses are adjusted for clustering within households using clustered robust standard errors.
e
72 contacts were clustered in 44 households.
f
The RR is the daily incremental risk.