Table 1. IC₅₀ values and gene mutation status of five lung cancer cell lines.

Cell Line	Tumor Subtype	KRAS	BRAF	EGFR	PIK3CA	LKB1	3p abnormalities	IC50 (MK2206 alone)	IC50 (MK2206+TUSC2)
H322	BA	wt	wt	wt	wt	E98-G155 deletion	inv(3p13)	20.39	1.24
HCC366	ADSQ	wt	wt	wt	wt	-2.5 Kb∼exon1 deletion	unknown	18.4	2.17
A549	AD	c,35G>A;p,G12S	wt	wt	wt	109C>T; Q37Ter	unknown	2.86	0.56
H358	BA	(c,35G>T;p,G12C),(c,35>T;p,G12V)	wt	wt	wt	wt	del(p14-p23), inv (3p)	6.92	7.47
H661	LC	wt	wt	wt	wt	wt	t(3p13;5p15)	8.43	8.16