Figure 1. Identification of genes associated with poor clinical outcome in 1q amplicon of breast tumors.

(A) High frequency amplification of 1q region in multiple cohorts of breast tumors. Graphs I – VI represent inferred copy-number of probes at chromosome 1 from the aCGH studies [61-66]. These graphical representations were the outcome of data visualized through Progenetix [67,68]. Copy number gain and loss are represented with green and red colors respectively. In all these five cohorts, 1q is amplified in 40 - 60 % of tumors. (B) Meta analysis – workflow for the identification 1q genes associated with patient survival. (C) Cox regression coefficient, hazard ratio and p-value of the shortlisted 1q genes, (D) Chromosomal map showing the locations of clinically significant 1q genes. (E) The identified 1q candidate genes showing an elevated expression in breast tumors when compared to the non-cancerous breast tissues in 3 different cohorts.