Table 4.

Kaplan–Meier (KM) and Cox regression (Cox) analyses on PFS and OS in patient groups dichotomised using threshold values of Table 3

Parameters	PFS-KM			PFS-Cox		OS-KM			OS-Cox
	Median survival (days)		p	Hazard ratio	p	Median survival (days)		p	Hazard ratio	p
	Group 0	Group 1				Group 0	Group 1
Sex	405	346	0.331			956	1610	0.685
Age	346	369	0.659			1610	1010	0.987
Site of primary	369	353	0.803			907	1709	0.069
Haemoglobin	564	366	0.474			776	1254	0.795
White cell count	373	286	0.241			1050	393	0.005	0.287	0.023
Platelets	373	227	0.508			1610	105	0.000	0.531	0.187
ALP	369	87	0.876			1050	941	0.556
LDH	426	327	0.020	0.685	0.158	1709	850	0.048	1.056	0.904
CEA	428	339	0.049	0.858	0.571	1709	907	0.006	0.516	0.307
Number of mets	428	316	0.006	0.540	0.022	1610	956	0.048	0.748	0.496
Surgery/RFA	339	435	0.027	1.618	0.075	764	1807	0.000	6.119	0.001
Response to chemotherapy	183	435	0.000	2.780	<0.001	907	1050	0.135
Liver lesion diameter	369	373	0.901			1807	941	0.031	1.404	0.606

ALP, alkaline phosphatase; CEA, carcionembryonic antigen; LDH, lactate dehydrogenase; OS, overall survival; PFS, progression-free survival; RFA, radiofrequency ablation.

After multivariate analysis, it was shown that number of metastases ≤2 and response to chemotherapy were associated with better PFS, whereas white cell count ≤10 and having received surgery or RFA to the liver metastases were associated with better OS.

Factors reaching statistical significance are highlighted in bold.