Table 2. Monoclonal expansions dominate the islet-infiltrating CD4⁺CD44^high T cell repertoire at diabetes onset¹.

Mouse2	TRBV gene	TRBJ gene	CDR3 sequence3	CDR3 Length4	Frequency5
8	15	2-1	SPGAEQFF	27	41.4
	1	1-1	SADNRVDTEVFF	39	17.1
10	19	1-3	STGTARSGNLYF	42	68.7
	1	2-5	SAGGQGLDTQYF	39	22.0
11	1	2-2	SASGQNTGQLYF	39	34.8
	13-3	1-2	SDPGGSDYTF	33	22.6
12	1	1-1	SAAQNTEVFF	33	53.7
	16	2-5	SFRDRKDTQYF	36	26.0
14	19	2-5	SAGTGGRQDTQYF	42	22.9
	19	2-5	RPWGNQDTQYF	36	15.9
15	13-3	1-6	SDRGTNSLYF	36	41.5
16	16	2-1	SLVGGNYAEQFF	39	35.6
	17	2-5	SREGVNQDTQYF	39	24.3
	19	2-2	SIWGGNTGQLYF	39	16.5

¹Monoclonal expansions are defined as clonotypes representing >15% of total CDR3β sequences.

²Numbers correspond to the diabetic mice identified in Table 1. Only the seven mice having monoclonal expansions are shown.

³Amino acid sequences between the conserved cysteine and phenylalanine residues, as defined by IMGT [57].

⁴CDR3 length of nucleotides.

⁵Raw frequency of each clonotype within the total CDR3β sequences obtained from each mouse.