FIGURE 2.

Intestine-specific ablation of MTP and ABCA1 decreases plasma lipids. Total RNA isolated from the intestine of 12-week-old WT, I-Mttp^−/−, I-Abca1^−/−, and I-DKO (n = 5) male mice fed a chow diet was used to quantify mRNA levels of MTP (A) and ABCA1 (B). Oil Red O staining of proximal intestine (C) and liver (D) sections showing lipid staining in these tissues. Plasma was separated by gel filtration to determine mass of triglycerides (E) and cholesterol (F) in different lipoproteins. Values are mean ± S.D. ***, p < 0.001 compared with WT.