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. 2013 Sep 6;288(42):30672–30681. doi: 10.1074/jbc.M113.472688

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© 2013 by The American Society for Biochemistry and Molecular Biology, Inc.

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FIGURE 5. — Calpain acts downstream of mPTP formation to mediate secondary integrin α_Iibβ₃ inactivation. A–C, fibrinogen-adherent platelets that were untreated (W/O MDL) or MDL-treated were stimulated with Thr/Cvx. A, morphology and TMRM fluorescence of control and MDL-treated platelets 1 and 10 min after stimulation. Scale bar = 5 μm. B and C, platelet rounding (B) and JON/A binding (C) in control and MDL-treated fibrinogen-adherent platelets stimulated with Thr/Cvx. n = 3. D, platelet aggregation in control and MDL-treated platelets. *, p < 0.05, n = 6. E, adherence of control and MDL-treated CypD^+/+ and CypD^−/− platelets in flow conditions. CTI/apyrase-treated whole blood was perfused at 1500 s over type I collagen in a microfluidics assay. Representative of n = 3. F, effect of MDL treatment on mPTP formation and PS exposure in control and MDL-treated cells assessed using TMRM and annexin V, respectively. n = 3 in each condition.