Table 2. Distribution of cases and controls, and odds ratios for pancreatic cancer associated with selected BER gene polymorphisms.
| Polymorphism | Genotype | No. of cases/controls (%) |
Unadjusted ORsa
(95% CI) |
Adjusted ORsb
(95% CI) |
| rs1799782 | CC | 88(47.57)/677(46.21) | 1.00 (ref.) | 1.00 (ref.) |
| (XRCC1, Arg194Trp) | CT | 80(43.24)/636(43.41) | 0.97 (0.70–1.33) | 0.96 (0.69–1.34) |
| TT | 17(9.19)/152(10.38) | 0.86 (0.50–1.49) | 0.81 (0.46–1.44) | |
| Per-allele model | 0.94 (0.75–1.19) | 0.96 (0.75–1.21) | ||
| Dominant model | 0.95 (0.70–1.29) | 0.93 (0.68–1.28) | ||
| (P trend) | 0.622 | 0.709 | ||
| minor allele(T) frequency in control subjects = 0.321 (HWEc: P = NS) | ||||
|
| ||||
| rs25487 | GG | 93(50.27)/842(57.47) | 1.00 (ref.) | 1.00 (ref.) |
| (XRCC1, Arg399Gln) | GA | 77(41.62)/538(36.72) | 1.30 (0.94–1.79) | 1.36 (0.98–1.90) |
| AA | 15(8.11)/85(5.80) | 1.60 (0.89–2.88) | 1.58 (0.85–2.93) | |
| Per-allele model | 1.28 (1.00–1.63) | 1.29 (1.01–1.65) | ||
| Dominant model | 1.34 (0.98–1.82) | 1.39 (1.01–1.92) | ||
| (P trend) | 0.046 | 0.043 | ||
| minor allele(A) frequency in control subjects = 0.242 (P = NS) | ||||
|
| ||||
| rs1130409 | TT | 77(41.62)/542(37.00) | 1.00 (ref.) | 1.00 (ref.) |
| (APE1, Asp148Glu) | TG | 75(41.62)/681(46.48) | 0.78 (0.55–1.09) | 0.77 (0.55–1.10) |
| GG | 33(17.84)/242(16.52) | 0.96 (0.62–1.48) | 1.02 (0.65–1.60) | |
| Per-allele model | 0.94 (0.75–1.16) | 0.96 (0.77–1.20) | ||
| Dominant model | 0.82 (0.60–1.12) | 0.84 (0.61–1.15) | ||
| (P trend) | 0.548 | 0.745 | ||
| minor allele(T) frequency in control subjects = 0.398 (P = NS) | ||||
|
| ||||
| rs1052133 | CC | 55(29.73)/417(28.46) | — | — |
| (OGG1, Ser326Cys) | CG | 87(47.03)/692(47.24) | — | — |
| GG | 43(23.24)/356(24.30) | — | — | |
| Per-allele model | — | — | ||
| Dominant model | — | — | ||
| (P trend) | — | — | ||
| minor allele(G) frequency in control subjects = 0.479 (P = 0.040) | ||||
|
| ||||
| rs1136410 | TT | 61(32.97)/550(37.54) | — | — |
| (PARP1, Val762Ala) | TC | 90(48.65)/657(44.85) | — | — |
| CC | 34(18.38)/258(17.61) | — | — | |
| Per-allele model | — | — | ||
| Dominant model | — | — | ||
| (P trend) | — | — | ||
| minor allele(T) frequency in control subjects = 0.400 (P = 0.012) | ||||
Abbreviation: OR, odds ratio.
aUnconditional logistic regression model (unadjusted).
bUnconditional logistic regression model adjusted for age, sex, current BMI, BMI at age 20, smoking status, drinking habit, history of diabetes mellitus, and family history of pancreatic cancer.
cHWE: Hardy–Weinberg Equilibrium.