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. 2013 Aug 15;305(8):C803–C816. doi: 10.1152/ajpcell.00198.2013

Table 2.

S-nitrosoproteome in pregnancy

Sequence Id Sequence Name Main Function Total Peptides L Log2 Rel Exp PTL Log2 Rel Exp
P21333 Filamin-A Cytoskeletal dynamics 175 −0.22 0.55
P02768 Serum albumin Transporter 78 −0.16 −1.44
P63267 Actin, gamma-enteric smooth muscle Smooth muscle contraction 48 0.11 0.53
P63261 Actin, cytoplasmic 2 Cytoskeletal dynamics 44 0.13 0.14
P17661 Desmin Cytoskeletal dynamics 39 0.1 1.25
Q9Y490 Talin-1 Cytoskeletal dynamics 33 −0.71 −2.48
P68871 Hemoglobin subunit-beta Transporter 26 −0.14 −2.22
P18206 Vinculin Cytoskeletal dynamics 26 −0.65 −1.53
P51911 Calponin-1 Smooth muscle contraction 26 −0.78 1.4
Q14315 Filamin-C Cytoskeletal dynamics 27 0 0.2
P04264 Keratin, type II cytoskeletal 1 Structural 25 −0.19 0.99
P14618 Pyruvate kinase isozymes M1/M2 Metabolic enzyme 23 0.41 −1.32
P35527 Keratin, type I cytoskeletal 9 Structural 21 −0.19 1.31
Q8WX93 Palladin Cytoskeletal dynamics 20 0.27 −1.42
Q93052 Lipoma-preferred partner Transporter and scaffolding 21 −0.08 −1.35
Q01995 Transgelin Cytoskeletal dynamics 18 −0.1 1.69
P06733 Alpha-enolase Metabolic enzyme 16 0.38 0.09
P04406 Glyceraldehyde-3-phosphate dehydrogenase Metabolic enzyme 15 −0.18 −0.12
P09211 Glutathione S-transferase P Nitric oxide signaling 13 0.39 −2.53
P02042 Hemoglobin subunit-delta Transporter 16 0.09 −1.83
P08670 Vimentin Cytoskeletal dynamics 17 −0.18 0.21
P09382 Galectin-1 Scaffolding 15 −0.26 −2.04
P13645 Keratin, type I cytoskeletal 10 Structural 13 −0.63 0.45
P35908 Keratin, type II cytoskeletal 2 epidermal Structural 13 0.22 0.9
P04792 Heat shock protein beta-1 Cytoskeletal dynamics 12 0.09 0.63
P12277 Creatine kinase B-type Metabolic enzyme 12 −0.25 −1.19
P69905 Hemoglobin subunit-alpha Transporter 13 −0.29 0.03
P12814 Alpha-actinin-1 Cytoskeletal dynamics 12 −0.36 −1.13
P67936 Tropomyosin alpha-4 chain Smooth muscle contraction 13 0.31 0.78
P13639 Elongation factor 2 Transcriptional regulation 10 0.05 −1.09
P10768 S-formylglutathione hydrolase Metabolic enzyme 10 0.4 −1.16
O00151 PDZ and LIM domain protein 1 Transcriptional regulation 10 −0.04 −1.27
P68363 Tubulin alpha-1B chain Structural 9 0.09 0.43
Q71U36 Tubulin alpha-1A chain Structural 9 0.09 0.43
O14558 Heat shock protein beta-6 Smooth muscle contraction 9 0.09 0.76
Q14195 Dihydropyrimidinase-related protein 3 Cytoskeletal dynamics 11 0.08 −0.04
P08133 Annexin A6 Smooth muscle contraction 10 0.25 −1.47
P07437 Tubulin beta chain Structural 9 −0.06 0.23
P07951 Tropomyosin beta chain Smooth muscle contraction 11 0.31 0.78
Q15746 Myosin light chain kinase, smooth muscle Smooth muscle contraction 9 0.17 −0.3
P62937 Peptidyl-prolyl cis-trans isomerase A Protein binding 9 −0.03 1.15
P48668 Keratin, type II cytoskeletal 6C Structural 9 0.06 1.29
P68371 Tubulin beta-4B chain Protein binding 8 −0.09 0.2
P21291 Cysteine and glycine-rich protein 1 Cytoskeletal dynamics 10 0.29 0.48
Q562R1 Beta-actin-like protein 2 Cytoskeletal dynamics 9 0.43 0.19
P01009 Alpha-1-antitrypsin Peptidase inhibitor 7 0.24 0.37
P55072 Transitional endoplasmic reticulum ATPase Protein binding and transport 8 −0.05 −0.76
P09493 Tropomyosin alpha-1 chain Cytoskeletal dynamics 9 0.31 0.78
Q6PEY2 Tubulin alpha-3E chain Structural 7 0.11 0.55
P54652 Heat shock-related 70 kDa protein 2 Protein binding 7 0.42 −1.55
P08779 Keratin, type I cytoskeletal 16 Structural 7 0.57 1.5
P04075 Fructose-bisphosphate aldolase A Metabolic enzyme 7 0.26 0.79
Q9NZN4 EH domain-containing protein 2 Cytoskeletal dynamics 6 0.12 −0.77
P07355 Annexin A2 Cytoskeletal dynamics 5 −0.42 −0.49
P13647 Keratin, type II cytoskeletal 5 Structural 6 −0.25 1.21
P02533 Keratin, type I cytoskeletal 14 Structural 6 0.43 1.7
P06396 Gelsolin Cytoskeletal dynamics 4 −0.28 0.67
Q15942 Zyxin Cytoskeletal dynamics 5 0.08 −0.56
P60660 Myosin light polypeptide 6 Smooth muscle contraction 6 0.21 1.58
P68104 Elongation factor 1-alpha 1 Transcriptional regulation 4 −0.07 −0.65
Q5VTE0 Putative elongation factor 1-alpha-like 3 Transcriptional regulation 4 −0.07 −0.65
P13489 Ribonuclease inhibitor Protein binding 4 0.21 −0.36
P07737 Profilin-1 Cytoskeletal dynamics 5 0.48 2.23
Q53GG5 PDZ and LIM domain protein 3 Cytoskeletal dynamics 5 −0.39 0.36
P23142 Fibulin-1 Protein binding 4 −0.55 −0.91
P37802 Transgelin-2 Cytoskeletal dynamics 5 0.48 1
Q01518 Adenylyl cyclase-associated protein 1 Cytoskeletal dynamics 4 0.3 −0.28
P21980 Protein-glutamine gamma-glutamyltransferase 2 Protein crosslinking 4 0.11 −2.34
Q09666 Neuroblast differentiation-associated protein AHNAK Protein binding 5 −0.18 0.46
Q15124 Phosphoglucomutase-like protein 5 Metabolic enzyme 4 0.16 −0.29
O43707 Alpha-actinin-4 Cytoskeletal dynamics 4 −0.38 −0.89
P31949 Protein S100-A11 Calcium signaling 4 0.45 0.26
P01857 Ig gamma-1 chain C region Protein binding 5 −0.53 0.34
P24844 Myosin regulatory light polypeptide 9 Smooth muscle contraction 3 0.37 1.82
Q99497 Protein DJ-1 Redox response 4 0.14 −1.11
P00387 NADH-cytochrome b5 reductase 3 Biosynthesis 4 0.6 −0.33
Q05682 Caldesmon Smooth muscle contraction 5 0.4 0.9
P00338 L-lactate dehydrogenase A chain Metabolic enzyme 3 −0.3 −0.41
P10809 60 kDa heat shock protein, mitochondrial Chaperone 2 −0.19 −0.5
Q9NR12 PDZ and LIM domain protein 7 Cytoskeletal dynamics 4 −0.6 0.13
Q16881 Thioredoxin reductase 1, cytoplasmic Redox response 3 0.21 −0.67
P01834 Ig kappa chain C region Protein binding 3 −0.32 0.33
P49419 Alpha-aminoadipic semialdehyde dehydrogenase Metabolic enzyme 3 0.69 −1.45
P02787 Serotransferrin Transporter 2 −0.44 0.31
O00299 Chloride intracellular channel protein 1 Redox response 3 0.46 −0.55
P02766 Transthyretin Transporter 3 −0.23 0.34
P04083 Annexin A1 Phospholipid binding 2 0.69 0.98
P50395 Rab GDP dissociation inhibitor beta GTPase regulation 2 0.38 −0.95
P04179 Superoxide dismutase [Mn], mitochondrial Redox response 2 0.66 0.07
Q9UBQ7 Glyoxylate reductase/hydroxypyruvate reductase Metabolic enzyme 2 0.1 −1.72
O60478 Integral membrane protein GPR137B G-Protein receptor 3 −0.72 0.83
P00441 Superoxide dismutase [Cu-Zn] Redox response 2 −0.22 0.5
P01861 Ig gamma-4 chain C region Protein binding 3 −0.24 0.66
P14550 Alcohol dehydrogenase [NADP+] Metabolic enzyme 2 0.74 −0.52
P02652 Apolipoprotein A-II Transporter 2 −1.51 −0.24
P62508 Estrogen-related receptor gamma Hormone receptor 3 −1.92 −2.04
P10599 Thioredoxin Redox response 2 0.22 1.04
P16591 Tyrosine-protein kinase Fer Cytoskeletal dynamics 3 −0.05 −1
P35754 Glutaredoxin-1 Redox response 2 −0.78 −0.28
P47756 F-actin-capping protein subunit-beta Cytoskeletal dynamics 2 −0.3 −1.1
P60953 Cell division control protein 42 homolog Cytoskeletal dynamics 2 0.12 −1.09
P31040 Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial Metabolic enzyme 2 −0.89 −2.42
Q13371 Phosducin-like protein Protein binding 2 −0.23 −0.33
P01876 Ig alpha-1 chain C region Protein binding 2 −0.17 −0.35
P06703 Protein S100-A6 Calcium signaling 2 −0.96 −0.06
Q9UMS6 Synaptopodin-2 Cytoskeletal dynamics 2 Not Id'd 10
Q6IE37 Ovostatin homolog 1 Proteinase inhibito 2 −1.11 −0.15
Q5SVZ6 Zinc finger MYM-type protein 1 Protein binding 2 −0.28 0.71
O75083 WD repeat-containing protein 1 Cytoskeletal dynamics 2 0.15 −1.08
Q9ULJ3 Zinc finger protein 295 Transcriptional regulation 2 −0.09 −1.34

There were 110 S-nitrosated proteins identified with 2 or more unique peptides. Log2 relative expressions for labor and preterm labor (L/PTL Rel Ex) for these 110 proteins are based on area under the curve analysis of all identified peptides using the nonlaboring state as reference. Note synaptopodin-2 was only positively identified in PTL.