Fig. 1.

Transforming growth factor-β1 (TGF-β1) impairs forskolin-stimulated anion secretion across PVD9902 monolayers. A: representative Ussing chamber recordings of vehicle or TGF-β1-treated (5 ng/ml, 24 h) PVD9902 monolayers exposed to forskolin (2 μM). Dashed lines represent the reference point of zero net current, indicating no net ion flux. Bar indicates the duration of symmetrical forskolin exposure. B: summarized results of forskolin-stimulated anion secretion from 7 paired experiments. *P < 0.05, significant difference between vehicle and TGF-β1-treated monolayers.