Fig. 2.

AMP-activated protein kinase (AMPK) activation in CON and skeletal muscle-specific LKB1-KO (skmLKB1-KO) gastrocnemius muscles after AICAR treatment and muscle contraction. A: AMPKα1 activity after saline or AICAR injection. B: AMPKα2 activity after saline or AICAR injection. C and D: AMPKα phosphorylation after saline or AICAR injection. E: AMPKα1 activity in resting (REST) and electrically stimulated (STIM) muscle. F: AMPKα2 activity in REST and STIM muscles. G and H: AMPKα phosphorylation in REST and STIM muscles. Data are presented as means ± SE; n = 5–6. ^aP < 0.05 vs. corresponding saline-treated (A–C) or resting muscle (E–G). ^bP < 0.05 vs. corresponding CON muscle.