Table 1.

Plasma metabolic profile

	WT 6 mo LFD	KO 6 mo LFD	WT 6 mo HFD	KO 6 mo HFD
TAG, mmol/l	0.62 ± 0.06	0.65 ± 0.04	1.44 ± 0.14###	1.25 ± 0.09###
NEFA, mmol/l	0.53 ± 0.03	0.74 ± 0.09	1.85 ± 0.14###	1.58 ± 0.17###
TNF-α, pg/ml	13.5 ± 4.6	5.9 ± 1.3	22.5 ± 7.1	15.5 ± 6.2
IL-6, pg/ml	17.6 ± 5.4	11.7 ± 4.5	34.3 ± 8.5	31.9 ± 9.1
Insulin, μg/l	0.07 ± 0.02	0.27 ± 0.09	1.95 ± 0.3###	2.87 ± 0.3*###
Leptin, ng/ml	13.34 ± 3.36	40.91 ± 13.36*	53.23 ± 7.75###	79.72 ± 5.72*##
Adiponectin, ng/ml	5,488 ± 678	4,902 ± 503	6,387 ± 503	5,296 ± 369

Values are means ± SE; n = 8 mice in each group. WT, wild type; LFD, low-fat diet; KO, knockout; TAG, triacylglycerol; NEFA, nonesterified fatty acid; TNF-α, tumor necrosis factor-α. Plasma was isolated from WT and IL-1 receptor I-deficient mice by cardiac puncture, and levels of metabolic markers were analyzed enzymatically (###P < 0.001, LFD vs. HFD; *P < 0.05, WT vs. KO).