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KATP conductance (gKATP) oscillations present in isolated β-cells were abolished by tolbutamide. Ramp voltage commands elicited oscillatory slope conductances in 3 of 4 isolated β-cells, detected using the Cluster algorithm (*, detected peaks). Tolbutamide (100 μM) blocked conductance oscillations and significantly decreased mean conductance (P < 0.05 with paired t-test). Data plotted are 2 point moving averages of raw conductance values.
