Table 1.
Parameters for simulations using the Dual Oscillator model
| Parameter | Original | Figs. 6, 7, 8B&D | Fig. 8A&C |
|---|---|---|---|
| Electrical | |||
| gK(Ca) (pS) | 300 | 100 | 100 |
| gK(ATP) (pS) | 16,000 | 10,000 | 18,000 |
| Vm (mV)a | −20 | −16 | −16 |
| kpmca (ms−1) | 0.1 | 0.15 | 0.15 |
| Metabolic | |||
| JGK (μM s−1)b | 0.4 | 0.18 | NA |
| K4 (μM) | 220 | 1000 | NA |
| kGPDH (μM ms−1) | 0.0005 | 0.0005 | 0 |
| JGPDH_bas (μM ms−1) | 0.0005 | 0.0005 | 0.002 |
The main changes were a reduction in maximal KATP conductance (gKATP) and flux through glucokinase (GK) to increase the range of gKATP in order to conform to the observations in the present study. The other changes were needed to restore the period to about 5 min and adjust spike amplitude. See appendix iii for further details on parameter changes and IV for computer codes used in the simulations
a
Half-maximal membrane potential for Ca2+ activation (not labeled in original)
b
Units corrected from original paper (5).