Table 1.
| 1993& | 1994& | 1995& | 2001 | 2002 | 2003 | 2004 | 2005 | 2006 | 2007 | 2008 | 2009 | 2010 | |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Registered live births# | 325994 | 322938 | 329581 | 260,354 | 247,530 | 227,070 | 216,419 | 205,854 | 204,459 | 204,414 | 198,733 | 191,310 | 166,886 |
| Maternal age ≧ 35 years | 16887 (5.18%) | 18112 (5.61%) | 20003 (6.07%) | 23046 (8.85%) | 21851 (8.83%) | 21468 (9.45%) | 21472 (9.92%) | 22635 (11.70%) | 23920 (11.70%) | 25260 (12.36%) | 26389 (13.28%) | 27683 (14.47%) | 28689 (17.19%) |
| Invasive prenatal diagnosis | 24985 (12.22%) | 26486 (12.96%) | 27645 (13.91%) | 31939 (16.69%) | 33553 (20.11%) | ||||||||
| Maternal age ≧ 35 years | 15,137 | 16,957 | 17,582 | 20,226 | 21,617 | ||||||||
| (Percentage) | 63.28% | 67.13% | 66.63% | 73.06% | 75.35% | ||||||||
| Maternal age < 35 years | 9,848 | 9,529 | 10,063 | 11,713 | 11,936 | ||||||||
| (Percentage) | 5.45% | 5.32% | 5.84% | 7.16% | 8.64% | ||||||||
| Registered live DS births | 30 | 50 | 23 | 58 | 49 | 48 | 41 | 50 | 59 | 50 | 45 | 43 | 13 |
| Registered DS stillbirths | 9 | 21 | 32 | 61 | 78 | 78 | 73 | 94 | 169 | 132 | 173 | 163 | 204 |
| Incidence of DS (per 100,000 live birth) | 12 | 22 | 17 | 46 | 51 | 55 | 53 | 70 | 112 | 89 | 110 | 108 | 130 |
| Liveborn DS/ total DS% | 76.92% | 70.42% | 41.82% | 48.74% | 38.58% | 38.10% | 35.96% | 34.72% | 25.88% | 27.47% | 20.64% | 20.87% | 5.99% |
| DS live birth rate (per 100,000 live birth) $ | 9.20 | 15.48 | 6.98 | 22.28 | 19.80 | 21.14 | 18.94 | 24.29 | 28.86 | 24.46 | 22.64 | 22.48 | 7.79 |
| DS stillbirth rate (per 100,000 live birth) $ $ | 2.76 | 6.50 | 9.71 | 23.43 | 31.51 | 34.35 | 33.73 | 45.66 | 82.66 | 64.57 | 87.05 | 85.20 | 122.24 |
| Registered live T18 births | 3 | 3 | 5 | 5 | 7 | 7 | 2 | 3 | 5 | 1 | |||
| Registered T18 stillbirths | 15 | 21 | 30 | 42 | 27 | 35 | 29 | 26 | 31 | 27 | |||
| Incidence of T18 | 0.73% | 0.99% | 1.55% | 2.16% | 1.64% | 2.05% | 1.52% | 1.48% | 1.87% | 1.68% | |||
| Liveborn T18/ total T18 | 16.67% | 12.50% | 14.29% | 10.64% | 20.59% | 16.67% | 6.45% | 10.34% | 13.89% | 3.57% | |||
| T18 live birth rate* | 1.21 | 1.24 | 2.22 | 2.3 | 3.38 | 3.41 | 0.98 | 1.53 | 2.6 | 0.6 | |||
| T18 stillbirth rate* | 6.07 | 8.69 | 13.32 | 19.32 | 13.05 | 17.07 | 14.26 | 13.24 | 16.11 | 16.2 | |||
| Registered live T13 births | 2 | 2 | 1 | 0 | 0 | 0 | 5 | 0 | 1 | 0 | |||
| Registered T13 stillbirths | 8 | 5 | 3 | 10 | 6 | 9 | 3 | 13 | 6 | 7 | |||
| Incidence of T13 | 0.40% | 0.29% | 0.18% | 0.46% | 0.29% | 0.44% | 0.39% | 0.66% | 0.36% | 0.42% | |||
| Liveborn T13/ total T13 | 20.00% | 28.57% | 25.00% | 0 | 0 | 0 | 62.50% | 0 | 14.29% | 0 | |||
| T13 live birth rate* | 0.81 | 0.83 | 0.44 | 0 | 0 | 0 | 2.46 | 0 | 0.52 | 0 | |||
| T13 stillbirth rate* | 3.24 | 2.07 | 1.33 | 4.6 | 2.9 | 4.39 | 1.48 | 6.62 | 3.12 | 4.2 | |||
| Registered TS live births | 0 | 2 | 3 | 2 | 3 | 3 | 1 | 2 | 1 | 1 | |||
| Registered TS stillbirths | 0 | 9 | 19 | 12 | 12 | 9 | 10 | 12 | 10 | 8 | |||
| Incidence of TS | 0 | 0.46% | 0.98% | 0.64% | 0.72% | 0.59% | 0.54% | 0.71% | 0.57% | 0.54% | |||
| Liveborn TS/ total TS | NA | 0.18 | 0.14 | 0.14 | 0.2 | 0.25 | 0.09 | 0.14 | 0.09 | 0.11 | |||
| TS live birth rate* | 0 | 0.83 | 1.33 | 0.92 | 1.45 | 1.46 | 0.49 | 1.02 | 0.52 | 0.6 | |||
| TS stillbirth rate* | 0 | 3.72 | 8.43 | 5.52 | 5.8 | 4.39 | 4.92 | 6.11 | 5.2 | 4.8 | |||
| Women receiving 1st trimester Down screening | 1367 | 3045 | 3038 | 3229 | 3210 | 7643 | 8921 | 11320 | 12443 | 14173 | |||
| Women receiving 2nd trimester quadruple Down screening | 27723 | 62136 | 67964 | ||||||||||
| Screening percentage | 0.50% | 1.20% | 1.30% | 1.50% | 1.50% | 3.70% | 4.30% | 19.70% | 38.30% | 48.70% |
# Data from the Department of statistics, Ministry of the Interior, executive yuan, Taiwan.
% Cochran-Armitage Trend Test, P<0.0001
$ Poisson regression for trend, p=0.32
$$ Poisson regression for trend, p<0.0001