Table 2.

	Total	First trimester screen Down syndrome risk	Second trimester quadruple test Down syndrome risk	Maternal age	Nuchal translucency (mm)	Karyotype	Remark
First trimester Down syndrome screening (9/2006-12/2011)	4106
High risk	127						Screening positive rate: 3.1%; Detection rate: 100%
		1/2		32	6	Trisomy 18	Terminated
		1/2		30	6.4	Trisomy 18	Terminated
		1/143		42	9.5	Trisomy 18	Terminated
		1/2		32	6	Trisomy 21	Terminated
		1/2		34	1.3	Trisomy 21	Terminated
		1/2		33	7.6	45,X	Cystic hygroma, terminated
		1/91		33	1.5	45,X	Terminated
		1/22		44	7.5	Trisomy 13	Megacystic, SUA, tachycardia, terminated
		1/111		33	3.6/3.1	both 46, XY	Twins, one IUFD at the 17th week of gestation
		1/2; 1/292		29	8.9/2.0	both 46, XY	Twins, one IUFD at the 15th week of gestation, hydrops fetalis
		1/102		35	3.5	6p25 microdeletion	Severe TR, AC, complex CHD, termination at the 17th week of gestation
		1/19		33	2	46, XX	Oligohydromnios and IUFD at the 23rd week of gestation
		1/47		30	2.8	46, XY	Thanotophoric dysplasia, terminated
		1/4		43	1.4	46, XY	Skeletal dysplasia, terminated at the 32nd week of gestation
Intermediate risk	211
		1/412		35	1.1	69,XXX	Immature fetus delivered spontaneously at 22 weeks; birth weight 170 g
		1/973		29	2.8	mos 47,XY,+21 [7]/46,XY[5]	Terminated
		1/305		29	3	46,xy	IUFD at the 22nd week of gestation
		1/828	1/5030	32	1.9	46,xy	Hydrops fetalis,terminated
		1/310	<1/38500	33	2.6		IUFD at the 23rd week of gestation
		1/749		29	2.3	46,X, del(Y) (q12)dn	Live birth
		1/672		32	1.7	45, X	Terminated
		1/302	1/61	30	1.8	46, XX	Live birth
Second trimester quadruple Down syndrome screening (5/2008-12/2011)	1307						Screening positive rate: 9.0%; Detection rate: 75%
High risk	118
			1/122	33		47, XX,+21	Terminated
			1/6	31		47, XY,+21	Terminated
			1/6	41		47, XY,+21	Terminated
			1/1110	41		47, XY,+21	Pregnancy at 18th week of gestation with multiple fetal anomalies, terminated