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. 2013 Jun 26;52(11):1952–1962. doi: 10.1093/rheumatology/ket219

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© The Author 2013. Published by Oxford University Press on behalf of the British Society for Rheumatology.

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@oup.com

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Fig. 5 — Increased expression of KIR3DL2 by leucocytes from HLA-B*27:05+ patients compared with HLA-B27− and HLA-B*27:05+ and HLA-B*27:09+ healthy controls (HCs).

(A) Left hand panel: percentage of NK cells expressing KIR3DL2 in HLA-B*27:05 + SpA patients, HLA-B*27:05+ HC, HLA-B*27:09 HC and HLA-B27 negative HC. Percentages of NK cells expressing KIR3DL2 were 35.6 ± 13.6 (mean ± 1s.d.), 20.3 ± 6.3 (P = 0.0004), 17.9 ± 11.3 (P = 0.0007) and 22.3 ± 8.5 (P = 0.007) for each of the respective groups. Right hand panel: level of expression of KIR3DL2 (ABC units) by SpA patient NK cells, HLA-B*27:05+, HLA-B*27:09+ and HLA-B27− HC. HLA-B*27:05+ SpA patients expressed 1571 ± 631.9 ABC units compared with 1038 ± 235.7 units (P = 0.003) for HLA-B*27:05 HC, 1049 ± 331.5 (P = 0.007) for HLA-B*27:09+ HC and 961 ± 318 units (P = 0.003) for HLA-B27 negative HC. (B) Left hand panel: percentages of CD4 T cells expressing KIR3DL2 in HLA-B*27:05 + SpA patients, HLA-B*27:05+, HLA-B*27:09 + and HLA-B27 negative HC. A mean of 1.8 ± 1.3 SpA CD4 T cells, 0.8 ± 0.4 HLA-B*27:05 HC (P = 0.01), 0.9 ± 0.3 B*27:09 HC (P = 0.009) and 1.0 ± 0.7 (P = 0.04) B27 negative HC expressed KIR3DL2. Right hand panel: SpA patient CD4 T cells expressed 1232 ± 513.8 ABC units of KIR3DL2, compared with 878.3 ± 199 HLA-B*27:05 HC (P = 0.011), 859.3 ± 288.7 HLA-B*27:09 HC (P = 0.016) and 847 ± 321 B27 negative HC (P = 0.030).