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DRA deletion (KO) inhibits net oxalate and Cl− absorption, resulting in net secretion of these anions in mouse cecum compared with WT littermates. A and B: unidirectional and net fluxes of oxalate [n = 19 (WT) and 10 (KO)] and Cl− [n = 6 (WT) and 8 (KO)] in separate populations of mice. C and D: combined Isc and GT values for all pairs used in the flux experiments. *Significantly different from WT (P ≤ 0.05 by unpaired t-test).
