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Wnt signaling pathway in the primary cilia. Binding of Wnt to Frizzled3 stabilizes β-catenin, which translocates to the nucleus and activates target genes with TCF/LEF by the canonical pathway. Instead of β-catenin, Dishevelled2 transmits signals to small GTPase or inositol 1,4,5-trisphosphate (IP3) receptor by the noncanonical pathway, which regulates the cytoskeleton and calcium respectively. ER, endoplasmic reticulum.
