Table 1.

Effects of calcitriol and paricalcitol on plasma and urinary parameters, body weight, food and water intake, and systolic blood pressure

	Groups
Parameter	Control	Calcitriol	Paricalcitol
Plasma Na+, mmol/l	140 ± 0.2	139 ± 0.2	139 ± 0.6
Plasma ionized Ca2+, mmol/l	1.24 ± 0.01	1.52 ± 0.03***	1.23 ± 0.02†††
PTH, pg/ml	43.5 ± 2.3	0.7 ± 0.7***	6.4 ± 3.2***
Plasma osmolality, mosmol/kgH2O	304 ± 4	305 ± 4	300 ± 3
24-h Urine volume, ml/24 h	11.3 ± 1.0	29.3 ± 3.4***	24.6 ± 3.2**
Urinary Na+ excretion, mmol/24 h	1.48 ± 0.10	1.73 ± 0.06	2.29 ± 0.23**†
Urinary Ca2+ excretion, mg/24 h	1.31 ± 0.19	11.7 ± 2.5**	9.2 ± 2.6*
Urinary PO43− excretion, mmol/24 h	0.72 ± 0.06	1.78 ± 0.16***	1.25 ± 0.10**††
Creatinine clearance, ml·min−1·g kidney wt−1	0.81 ± 0.07	0.89 ± 0.07	0.66 ± 0.05
Urine osmolality, mosmol/kgH2O	1,623 ± 108	786 ± 92***	1,045 ± 137**
Basal body weight, g	236 ± 5	234 ± 5	244 ± 4
Final body weight, g	274 ± 2	249 ± 5**	272 ± 4††
Food consumed, g/day	17.9 ± 1.0	14.4 ± 0.8*	17.1 ± 0.5†
H2O consumed, ml/day	45 ± 3	53 ± 5	51 ± 2
Systolic blood pressure, mmHg	128 ± 9	132 ± 8	130 ± 4

Values are means ± SE.

^*P < 0.05 vs. control. PTH, parathyroid hormone.

^**P < 0.01 vs. control.

^***P < 0.001 vs. control.

^†P < 0.05 vs. calcitriol.

^††P < 0.01 vs. calcitriol.

^†††P < 0.001 vs. calcitriol.