Table 3.

Effects of β-blockade with propranolol on plasma, urinary, and body weight parameters from control and calcitriol-treated rats

	Control	Control+Propranolol	Calcitriol	Calcitriol+Propranolol
Plasma Na+, mmol/l	139 ± 0.4	139 ± 0.4	138 ± 0.4	139 ± 0.6
Plasma ionized Ca2+, mmol/l	1.19 ± 0.02	1.19 ± 0.02	1.36 ± 0.03***	1.39 ± 0.04‡‡‡
Plasma osmolality, mosmol/kgH2O	296 ± 1	296 ± 2	308 ± 1***	308 ± 2‡‡‡
24-h Urine volume, ml/24 h	10.9 ± 1.1	10.1 ± 1.2	32.6 ± 2.8***	34.9 ± 3.0‡‡‡
Urinary Na+ excretion, mmol/24 h	1.35 ± 0.17	1.54 ± 0.14	2.28 ± 0.10***	1.77 ± 0.18†
Urinary Ca2+ excretion, mg/24 h	1.20 ± 0.40	0.91 ± 0.21	10.57 ± 2.93**	8.15 ± 1.83‡
Creatinine clearance, ml·min−1·g kidney wt−1	0.48 ± 0.03	0.57 ± 0.05	0.59 ± 0.05	0.62 ± 0.05
Urine osmolality, mosmol/kgH2O	1,439 ± 157	1,580 ± 196	809 ± 46**	691 ± 57‡‡‡
Basal body weight, g	244 ± 6	244 ± 7	244 ± 4	243 ± 4
Final body weight, g	272 ± 6	270 ± 6	259 ± 6	243 ± 5‡‡†
Food consumed, g/day	17.0 ± 0.6	16.1 ± 0.5	16.2 ± 0.4	13.4 ± 0.6‡‡†††
H2O consumed, ml/day	39 ± 3	39 ± 2	62 ± 4***	59 ± 2‡‡‡

Values are means ± SE.

^**P < 0.01 vs. control.

^***P < 0.001 vs. control

^‡P < 0.05 vs. control+propranolol.

^‡‡P < 0.01 vs. control+propranolol.

^‡‡‡P < 0.001 control+propranolol.

^†P < 0.05 vs. calcitriol.

^†††P < 0.001 vs. calcitriol.