Fig. 1.

Enhanced colonic inflammation in immunity-related GTPase (Irg) M (Irgm)-deficient (Irgm1 KO) mice receiving dextran sodium sulfate (DSS). Male wild-type (WT) and Irgm1 KO mice were given 3% DSS in drinking water (DSS) or maintained on standard drinking water (control) for 7 days. A–C: clinical indicators of inflammation [average body weight, average stool consistency score, and average bleeding (Hemoccult) index] at days 0–7. D: average colon length at necropsy. E: representative histological tissue sections from transverse colon (hematoxylin-eosin stain; ×100 magnification). F: average histological scores from proximal (Prox), transverse (Trans), and distal (Dist) colon and cecum. Values are means ± SE; data were combined from 3 separate studies. Combined cohort sizes were as follows: n = 9 WT control and WT DSS and 7 KO control and KO DSS. *P < 0.05, **P < 0.005 (KO DSS vs. WT DSS).