Fig. 3.

Paneth cell abnormalities in Irgm1 KO mice. A and B: histological staining with hematoxylin and eosin (A; ×400 magnification) and transmission electron microscopy (B; ×5,000 magnification) of ileal tissues from untreated WT and Irgm1 KO mice. C: lysozyme (Lyz) immunohistochemical staining of ileal tissue from control and DSS-treated WT and KO mice (×200 magnification). D: total number of lysozyme (Lyz)-positive cells (left) and Lyz-positive cells above the base of the crypt (ectopic, right). Values are means ± SE; data were collected from 3 individual mice for each group, with ≥10 crypt-villus units per mouse. *P < 0.05.