Fig. 8.
Transcript expression of selected genes altered in Atg16L1HM mice. Atg16L1-deficient Paneth cells have been shown to exhibit increased expression of genes involved in peroxisome proliferator-activated receptor (PPAR) pathways, adipocytokine signaling, lipid metabolism, and acute-phase reactant responses. Ileal mRNA expression of specific transcripts enriched in Atg16L1-deficient Paneth cells, relevant to these pathways, was evaluated in untreated WT and Irgm1 KO mice by quantitative RT-PCR. A: stearoyl-coenzyme A desaturase 1 (Scd1), involved in lipid metabolism. B: adiponectin (Adipoq), involved in adipocytokine signaling. C: serum amyloid A1 (Saa1), involved in acute-phase reactant response. D: leptin (Lep), involved in adipocytokine signaling and the PPAR pathway. Values are means ± SE; n = 9 WT and KO. No significant differences were observed for any of the transcripts tested (P > 0.2).