Table 1.

Renal excretory responses to chronic infusion of a high dose (25 ng/min) of ANG II (ANG II-H) with or without tempol (Temp) in wild-type and eNOS knockout mice

Animal groups	WT–ANG II-H			WT–ANG II-H +Temp			KO–ANG II-H			KO–ANG II-H +Temp
Day of Treatment	0	7th	13th	0	7th	13th	0	7th	13th	0	7th	13th
Urine flow, mL/day	1.82 ± 0.19	1.67 ± 0.39	4.49 ± 1.42*	1.42 ± 0.22	2.20 ± 0.20*	2.12 ± 0.40	1.22 ± 0.16	1.36 ± 0.41	No urine- All animals died	1.56 ± 0.28	2.09 ± 0.22	1.01 ± 0.28
UNaV, mmol/day	0.48 ± 0.04	0.33 ± 0.07	0.81 ± 0.26*	0.17 ± 0.02	0.19 ± 0.02	0.21 ± 0.04	0.31 ± 0.03	0.26 ± 0.08		0.15 ± 0.03	0.20 ± 0.03	0.09 ± 0.03
UKV, mmol/day	1.11 ± 0.12	0.60 ± 0.13	0.84 ± 0.21	0.27 ± 0.03	0.56 ± 0.12	0.63 ± 0.14	0.64 ± 0.06	0.43 ± 0.15		0.21 ± 0.04	0.26 ± 0.04	0.23 ± 0.05

U_NaV, urinary sodium excretion; U_KV, urinary potassium excretion; WT, wild type; KO, knockout.

^*P < 0.05 vs. baseline values at −1 day.