Table 2.

Renal excretory responses to chronic infusion of a low dose (10 ng/min) of ANG II-L in wild-type mice

Animal groups	WT–ANG II-L (n = 6)			WT–ANG II-L+Temp (n = 6)			WT–ANG II-L+ETN (n = 6)			WT–ETN (n = 6)
Day of Treatment	0	7th	13th	0	7th	13th	0	7th	13th	0	7th	13th
Urine flow, ml/day	1.69 ± 0.23	1.30 ± 0.29	1.60 ± 0.30	1.31 ± 0.14	1.30 ± 0.14	1.17 ± 0.14	1.74 ± 0.15	1.14 ± 0.17	1.12 ± 0.48	1.84 ± 0.17	1.15 ± 0.11	0.65 ± 0.13*
UNaV, mmol/day	0.15 ± 0.015	0.15 ± 0.03	0.12 ± 0.02	0.16 ± 0.01	0.18 ± 0.01	0.15 ± 0.02	0.20 ± 0.02	0.17 ± 0.03	0.08 ± 0.01*	0.20 ± 0.02	0.17 ± 0.03	0.08 ± 0.01*
UKV, mmol/day	0.43 ± 0.13	0.37 ± 0.07	0.37 ± 0.08	0.31 ± 0.05	0.41 ± 0.04	0.40 ± 0.05	0.51 ± 0.10	0.29 ± 0.02	0.12 ± 0.03	0.53 ± 0.04	0.26 ± 0.02	0.70 ± 0.01
UNOxV, μmol/day	0.27 ± 0.10	0.39 ± 0.15	0.74 ± 0.37*	0.41 ± 0.09	0.56 ± 0.06	0.93 ± 0.30*	1.25 ± 0.21	0.89 ± 0.35	0.75 ± 0.15	1.55 ± 0.40	1.81 ± 0.68	2.53 ± 0.57
UISOV, ng/day	1.0 ± 0.2	1.8 ± 0.4*	1.5 ± 0.4*	1.9 ± 0.1	2.5 ± 0.6	2.1 ± 0.3	1.7 ± 0.5	2.1 ± 0.7	3.3 ± 0.9*	1.3 ± 0.3	1.5 ± 0.1	2.3* ± 0.3

Temp, tempol; ETN, etanercept; U_NOxV, urinary nitrate/nitrite excretion; U_ISOV, urinary isoprostane excretion; Temp, tempol; ETN, etanercept.

^*P < 0.05 vs. baseline values at −1 day.