Table 3.
eQTLs with LRS > 15.0 from the chromosome 11 QTL at 83–95 Mb in ethanol- and CCl4-damaged livers in vivo ranked by chromosomal location (proximal to distal) and LRS
| eQTL Location | LRS | Gene Symbol | Description | Gene Location |
|---|---|---|---|---|
| Etiology: Ethanol | ||||
| 83.521935 | 57.8 | Dhx40 | DEAH (Asp-Glu-Ala-His) box polypeptide 40; last two exons and 3′-UTR | 86.6 |
| 83.521935 | 47.2 | Ggnbp2 | gametogenetin binding protein 2 | 84.7 |
| 83.521935 | 42.4 | BC022224 | cDNA sequence BC022224 | 84.6 |
| 83.521935 | 38.3 | Acac | acetyl-Coenzyme A acyltransferase 2 (mitochondrial 3-oxoacyl-Coenzyme A thiolase) | 84.1 |
| 83.521935 | 36.8 | Rps6kb1 | ribosomal protein S6 kinase, polypeptide 1; last three exons and proximal 3′-UTR | 86.3 |
| 83.521935 | 32.7 | 2700008B19Rik | RIKEN cDNA 2700008B19 gene; distal end of last exon and proximal 3′-UTR | 83.6 |
| 83.521935 | 30.5 | Acac | acetyl-Coenzyme A acyltransferase 2 (mitochondrial 3-oxoacyl-Coenzyme A thiolase) | 84.1 |
| 83.521935 | 28.5 | Acac | acetyl-Coenzyme A acyltransferase 2 (mitochondrial 3-oxoacyl-Coenzyme A thiolase); distal 3′-UTR | 84.2 |
| 83.521935 | 25.4 | Cltc | clathrin, heavy polypeptide (Hc); mid-3′-UTR | 86.5 |
| 83.521935 | 25.1 | Bcas3 | breast carcinoma amplified sequence 3 | 85.4 |
| 83.521935 | 20.5 | Aatf | apoptosis antagonizing transcription factor; exons 4, 5, 7, 8 and 9 | 84.2 |
| 83.521935 | 16.9 | Pigx | phosphatidylinositol glycan, class X | Chr16: 32.1 |
| 83.521935 | 16.0 | Acat1 | acetyl-Coenzyme A acetyltransferase 1 | Chr9: 53.4 |
| 83.521935 | 15.8 | Ash1l | ash1 (absent, small, or homeotic)-like (Drosophila) | Chr3: 88.8 |
| 83.521935 | 15.8 | 1110054O05Rik | RIKEN cDNA 1110054O05 gene | Chr4: 59.8 |
| 87.668081 | 39.5 | Msi2 | Musashi RNA-binding protein 2; mid-3′-UTR | 88.2 |
| 87.668081 | 18.0 | Usp32 | ubiquitin specific protease 32; distal 3′-UTR (transQTL on Chr 4 in BXD eye data) | 84.8 |
| 87.668081 | 17.6 | Wdr53 | WD repeat domain 53 | Chr16: 32.3 |
| 87.668081 | 17.1 | Ldhd | lactate dehydrogenase D | Chr8: 114.2 |
| 87.668081 | 17.0 | Grm1 | glutamate receptor, metabotropic 1 (group I, PLC-IP3 coupled); last exon and proximal 3′-UTR | Chr10: 10.4 |
| 87.668081 | 16.8 | Sfrs1 | splicing factor, arginine/serine-rich 1 (ASF/SF2); distal 3′-UTR | 87.9 |
| 87.668081 | 16.6 | C130020C13Rik | RIKEN cDNA C130020C13 gene | Chr5: 34.2 |
| 87.668081 | 16.3 | Adam4 | a disintegrin and metalloprotease domain 4 | Chr12: 82.5 |
| 87.668081 | 16.2 | Mapk12 | mitogen-activated protein kinase 12 | Chr15: 89.0 |
| 87.668081 | 15.5 | Epn2 | epsin 2; middistal 3′-UTR | 61.3 |
| 87.668081 | 15.2 | Pmvk | phosphomevalonate kinase | Chr3: 89.3 |
| 88.522933 | 29.3 | 2210409E12Rik | RIKEN cDNA 2210409E12 gene | 88.8 |
| 88.522933 | 24.1 | 2700008B19Rik | RIKEN cDNA 2700008B19 gene | 83.6 |
| 88.522933 | 18.0 | Appbp2 | amyloid beta precursor protein (cytoplasmic tail) binding protein 2; far 3′-UTR | 85.1 |
| 88.522933 | 17.9 | 5730526G10Rik | RIKEN cDNA 5730526G10 gene | Chr9: 15.2 |
| 88.522933 | 17.0 | CR517518 | CR517518 EST in olfactory receptor cluster (EST associated with similarity to erythroid differentiation regulator); unknown, perhaps intron of Or1 g1 | Chr19: 11.9 |
| 88.937291 | 18.2 | Rae1 | RAE1 RNA export 1 homolog (S. pombe) | N/A |
| 88.937291 | 16.2 | Nfkbib | nuclear factor of kappa light chain gene enhancer in B-cells inhibitor, beta | Chr7: 29.5 |
| 88.937291 | 15.8 | Pnma1 | paraneoplastic antigen MA1 | Chr12: 85.5 |
| 89.612736 | 23.2 | Trygn16 | trypsinogen 16 | Chr6: 41.4 |
| 89.612736 | 17.8 | Nrbf1 | nuclear receptor binding factor 1 | Chr4: 131.4 |
| 89.612736 | 15.1 | Rabgef1 | RAB guanine nucleotide exchange factor (GEF) 1; last exon and proximal 3′-UTR | Chr5: 130.7 |
| 89.938911 | 16.0 | Bcl11a | B-cell CLL/lymphoma 11A (zinc finger protein) | 24.0 |
| 90.203179 | 23.2 | Pctp | phosphatidylcholine transfer protein; distal half of 3′-UTR | 89.8 |
| 90.203179 | 15.5 | Pctp | phosphatidylcholine transfer protein; last 3 exons and 3′-UTR | 89.9 |
| 90.664416 | 25.6 | Stxbp4 | syntaxin binding protein 4; 3′-UTR | 90.3 |
| 90.664416 | 20.1 | Gdpd1 | glycerophosphodiester phosphodiesterase domain containing 1 | 86.5 |
| 90.664416 | 17.3 | Foxo1 | forkhead box O1; last intron | Chr3: 52.1 |
| Etiology: CCl4 | ||||
| 83.521935 | 37.1 | Dhrs11 | dehydrogenase/reductase (SDR family) member 11 | 84.6 |
| 83.521935 | 26.2 | Myo19 | myosin XIX | 84.7 |
| 83.521935 | 23.9 | Affy_10358428 | Affymetrix Mouse Gene 1.0 ST probe set 10358428 | Chr1: 146.8 |
| 83.521935 | 22.2 | Affy_10502482 | Affymetrix Mouse Gene 1.0 ST probe set 10502482 | Chr3: 142.4 |
| 83.521935 | 22.0 | Appbp2 | amyloid beta precursor protein (cytoplasmic tail) binding protein 2 | 85.0 |
| 83.521935 | 21.7 | Cuedc1 | CUE domain containing 1 | 87.9 |
| 83.521935 | 18.1 | Affy_10339384 | Affymetrix Mouse Gene 1.0 ST probe set 10339384 | N/A |
| 83.521935 | 17.9 | Serpinh1 | serine (or cysteine) peptidase inhibitor, clade H, member 1 | Chr7: 106.5 |
| 83.521935 | 16.4 | Ipp | IAP promoted placental gene | Chr4: 116.2 |
| 83.521935 | 16.2 | Affy_10491484 | Affymetrix Mouse Gene 1.0 ST probe set 10491484 | Chr3: 35.6 |
| 83.521935 | 15.3 | Zfp616 | zinc finger protein 616 | 73.9 |
| 83.521935 | 15.3 | Txlng | taxilin gamma | Chr5: 105.2 |
| 88.522933 | 31.1 | Dhx40 | DEAH (Asp-Glu-Ala-His) box polypeptide 40 | 86.6 |
| 88.522933 | 17.2 | mir-465a | Affymetrix Mouse Gene 1.0 ST probe set 10604877 | ChrX: 64.1 |
| 88.522933 | 16.9 | Xlr3a | X-linked lymphocyte-regulated 3A | ChrX: 70.3 |
| 88.522933 | 16.6 | Gm15698 | predicted gene 15698 | 88.8 |
| 88.522933 | 15.7 | Affy_10466841 | Affymetrix Mouse Gene 1.0 ST probe set 10466841 | Chr19: 25.5 |
| 88.522933 | 15.3 | Saa3 | serum amyloid A 3 | Chr7: 54.0 |
| 88.522933 | 15.2 | Bsdc1 | BSD domain containing 1 | Chr4: 129.1 |
| 89.612736 | 21.3 | Pctp | phosphatidylcholine transfer protein | 89.8 |
| 89.612736 | 19.5 | Fuz | fuzzy homolog (Drosophila) | Chr7: 52.2 |
| 89.612736 | 16.5 | Gm5712 | predicted gene 5712 | Chr3: 129.1 |
eQTL, expression quantitative trait locus; LRS, likelhood ratio statistic; CCl4, carbon tetrachloride.