Fig. 3.

Alveolarization is decreased in the sGC-α1 KO mouse pup lung. Representative images of toluidine blue-stained sections of mouse pup lungs that were inflation fixed at postnatal day 3 (P3) and 13 (P13). A: peripheral lung structure of P3 sGC-α1 KO pup lungs appeared to be similar to that of WT ones. B: in contrast, P13 sGC-α1 KO pup lungs had fewer and larger airspace structures than WT ones at the indicated oxygen exposure levels. The most severe lung phenotype was observed in the sGC-α1 KO mouse pups exposed to 70% O₂. Scale bar = 20 μm.