Fig. 6.

Lung volume (LV) is decreased in sGC-α1 KO mouse pups, and 70% oxygen exposure decreased sGC-α1 KO mouse pup body weight. A: LV and LV-to-body weight ratio of 13-day-old mice. N = 12–14 mice per group. *P < 0.05. B: relationship between total pup weights and pup numbers in a litter. Each point represents data from 1 13-day-old litter; lines are linear regression models. All groups exhibit an effect of litter size on weight. Air-exposed WT and sGC-α1 KO litters and 70% oxygen-exposed WT litters showed similar growth, whereas sGC-α1 KO litters exposed to 70% oxygen had decreased growth (P < 0.05).