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PPARα and DEC1 are Per1 and Clock target genes. AML12 cells were treated with nontarget, Per1, Clock siRNA or a combination of Per1 and Clock siRNA for 48 h. QPCR was used to evaluate changes in Per1 (A), Clock (B), PPARα (C), and DEC1 (D) expression in Per1, Clock, or Clock/Per1 siRNA treated cells vs. nontarget siRNA control; n = 4; *P < 0.05, **P < 0.01, ***P < 0.001. Values are means ± SE.
