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Comparison of the criteria for diabetic nephropathy in human patients and streptozotocin-treated Dahl salt-sensitive rats
| Criteria | Human | STZ-SS |
|---|---|---|
| Early increase in GFR (hyperfiltration) | √ | √ |
| Progressive proteinuria | √ | √ |
| Hypertension | √ | √ |
| Mesangial matrix expansion | √ | √ |
| Thickening of glomerular basement membrane | √ | √ |
| Renal interstitial fibrosis | √ | √ |
| Nodular glomerular lesions | √ | √ |
| Decline in GFR | √ | √ |
GFR, glomerular filtration rate; STZ-SS, streptozotocin-treated Dahl salt-sensitive.
