Fig. 5.

Experimental records illustrating the effect of pretreatment with HC-030031 on the responses of a CSLV afferent to capsaicin injection (1 μg/kg, arrows) before and 5 and 30 min after the termination of the airway exposure to aerosolized NaHS (5 mg/ml, 3 min) in an anesthetized, artificially ventilated rat. A and B: before and after pretreatment with HC-030031 (an antagonist of TRPA1 receptors; 8 mg/kg), respectively. Note that pretreatment with HC-030031 blocked the sensitizing effect of NaHS on the fiber response to the capsaicin injection.