Fig. 6.

The effects of pretreatment with HC-030031 on the CSLV-fiber sensitization induced by NaHS, allyl isothiocyanate (AITC), or prostaglandin E₂ (PGE₂) in 6 groups of rats. The NaHS (A–D; 5 mg/ml, 3 min) was provided through aerosol inhalation, and AITC (E; an agonist of TRPA1 receptors; 0.4 mg·kg⁻¹·min⁻¹, 2 min) and PGE₂ (F; a sensitizer of CSLV afferents; 3 μg·kg⁻¹·min⁻¹, 2 min) were applied by intravenous infusion. Top and bottom: responses to capsaicin injections; middle: response to lung inflation. ^aSignificantly different from the value before the sensitizing agents in the same group (P < 0.05). *Significantly different from the value at the corresponding time period before pretreatment (P < 0.05). Data in each group are means ± SE of 8 fibers recorded from 8 rats. See Fig. 2 for further explanation.