Fig. 5.

Metabolic parameters analyzed by the cosinor method. A: the least-squares spectrum of oxygen consumption (V̇o₂) of the fat POKO mice was lower than group average and lean mice, most pronounced for the 24-h amplitude, and lower in female fat POKO than male fat POKO. B: the least-squares spectrum of XTOT of the fat POKO mice was lower than the lean POKO or WT groups, shown in the 24 h, 12 h, 8 h, 6 h, and 4.8 h rhythms. C: when all POKO male and females were compared with their respective WT groups of the same sex, POKO male had a reduced MESOR of V̇o₂ (top), whereas POKO female had a reduced MESOR of XTOT (bottom). *P < 0.05.